From the airport
Train: You have the chance to take the S8 from the Frankfurt Airport for the station "Frankfurt Hauptbahnhof". From there you can take the EC219 to get to central station "Heidelberg Hauptbahnhof". The hotel is reachable in a walking distance from about 10 minutes. It's a 80 minutes trip. You can choose between a single ticket (1,70€), a day ticket ( 7€) or a ticket for three days (16,60€). Within the ticket price you can take the train, as well as the bus in Heidelberg.
Taxi: The trip takes 50 minutes and costs around 175-200€.
Aerobus shuttle: There is the opportunity to take the Lufthansa Airport shuttle from the Frankfurt Airport to get to the hotel. You can view the schedule and make a booking here or contact the hotel directly.