From either airport, the drive takes approximately 1 hour and 15 minutes.

Driving directions from Vigo Airport:

Go straight through two roundabouts.
At the third roundabout, take the 1st exit.
Turn right onto Calle del Porto Vello.
Turn left onto Calle Díaz de la Banda, and continue onto Calle de Mañuel Fernández García.
Turn right onto Avenida de Otero Pedrayo.
When you reach the roundabout at Plaza de Mañuel Curros Enríquez, take the 2nd exit onto Calle de Curros Enríquez.
Turn left onto Calle de Celso Emilio Ferreiro. The hotel is located at number 22.

Driving directions from Santiago de Compostela Airport:

After leaving the airport, at the roundabout take the 3rd exit onto AC-250.
At the next roundabout, take the 3rd exit onto the A-54 ramp to Santiago.
At the roundabout, take the 3rd exit onto the SC-20 ramp towards Santiago (Centro).
Merge onto the Carretera Coruña-Tui and get off at the exit towards E-1/AP-9/A Coruña/Pontevedra/N-525/AP-53/Ourense.
At the roundabout take the 3rd exit onto the E-1/AP-9 ramp.
Merge onto the E-1/AP-9 and continue on this highway for 56 km.
The highway will become AG-53 and you will see signs for Ourense. Continue for 30 km and get off at the exit for A-52.
Follow signs for and merge onto A-52 toward Ourense.
Stay on A-52 for 9 km and take Exit 230 toward OU-11/Ourense.
Continue straight and then take a slight left onto Avenida de Ribeira Sacra.

Go straight through two roundabouts.
At the third roundabout, take the 1st exit.
Turn right onto Calle del Porto Vello.
Turn left onto Calle Díaz de la Banda, and continue onto Calle de Mañuel Fernández García.
Turn right onto Avenida de Otero Pedrayo.
When you reach the roundabout at Plaza de Mañuel Curros Enríquez, take the 2nd exit onto Calle de Curros Enríquez.
Turn left onto Calle de Celso Emilio Ferreiro. The hotel is located at number 22.

Walking directions from the train station:

Proceed down Avenida de las Caldas away from the train station. Continue across the Roman Bridge over the river. When you reach Plaza Concepción Arenal, turn left onto Avenida de la Habana. After 450 meters, turn left onto Calle del Cardenal Quevedo and then right onto Calle de Celso Emilio Ferreiro. The hotel is located at number 22. 

The walk takes approximately 20 minutes. Alternatively, you can take a taxi.

From Madrid

From the A-52 highway, take Exit 228 toward OU-11/Ourense.
Arrive in Ourense.
Bear left onto Avenida de Ribeira Sacra / Carretera de Ponferrada.
At the roundabout Avenida de Ribeira Sacra, take the 1st exit: N-120 / Calle de los Remedios / Rúa Dos Remedios.
At the roundabout Avenida de Pardo de Cela, take the 3rd exit: Avenida de Pardo de Cela.
Continue along Calle del Progreso / Rúa Do Progreso.
Turn left at Calle del Concello / Rúa Do Concello.
Continue left on Calle del Concello / Rúa Do Concello.
Turn right at Calle de Sáenz Díez / Rúa de Sáenz Díez.
Turn right at Calle de Samuel Eiján / Rúa de Samuel Eiján.
Turn left at Calle de Curros Enríquez / Rúa de Curros Enríquez.
Turn right at Calle de Celso Emilio Ferreiro / Rúa de Celso Emilio Ferreiro.
Arrive at destination: NH Ourense, Rúa de Celso Emilio Ferreiro 24.

FROM VIGO

From the A-52 highway, take Exit 228 toward OU-11/Ourense.
Arrive in Ourense.
Bear left onto Avenida de Ribeira Sacra / Carretera de Ponferrada
At the roundabout Avenida de Ribeira Sacra, take the 1st exit: N-120 / Calle de los Remedios / Rúa Dos Remedios.
At the roundabout Avenida de Pardo de Cela, take the 3rd exit: Avenida de Pardo de Cela.
Continue along Calle del Progreso / Rúa Do Progreso.
Turn left at Calle del Concello / Rúa Do Concello.
Continue left on Calle del Concello / Rúa Do Concello.
Turn right at Calle de Sáenz Díez / Rúa de Sáenz Díez.
Turn right at Calle de Samuel Eiján / Rúa de Samuel Eiján.
Turn left at Calle de Curros Enríquez / Rúa de Curros Enríquez.
Turn right at Calle de Celso Emilio Ferreiro / Rúa de Celso Emilio Ferreiro.
Arrive at destination: NH Ourense, Rúa de Celso Emilio Ferreiro 24.

FROM SANTIAGO

From the A-52 highway, take Exit 228 toward OU-11/Ourense.
Arrive in Ourense.
Bear left onto Avenida de Ribeira Sacra / Carretera de Ponferrada.
At the roundabout Avenida de Ribeira Sacra, take the 1st exit: N-120 / Calle de los Remedios / Rúa Dos Remedios.
At the roundabout Avenida de Pardo de Cela, take the 3rd exit: Avenida de Pardo de Cela.
Continue along Calle del Progreso / Rúa Do Progreso.
Turn left at Calle del Concello / Rúa Do Concello.
Continue left on Calle del Concello / Rúa Do Concello.
Turn right at Calle de Sáenz Díez / Rúa de Sáenz Díez.
Turn right at Calle de Samuel Eiján / Rúa de Samuel Eiján.
Turn left at Calle de Curros Enríquez / Rúa de Curros Enríquez.
Turn right at Calle de Celso Emilio Ferreiro / Rúa de Celso Emilio Ferreiro.
Arrive at destination: NH Ourense, Rúa de Celso Emilio Ferreiro 24.